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Sofosbuvir (Sovaldi)

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Welcome to the Best Place to Buy Sovaldi Online. SOVALDI is a prescription medicine used with other antiviral medicines to treat chronic (lasting a long time) hepatitis C infection in adults. Buy Sovaldi Online You should not take SOVALDI alone. SOVALDI should be used together with ribavirin or in combination with peginterferon alfa and ribavirin to treat chronic hepatitis C infection. The recommended dose of SOVALDI is one 400 mg tablet, taken orally, once daily with or without food.

INDICATIONS AND USAGE 

SOVALDI is a hepatitis C virus (HCV) nucleotide analog NS5B polymerase inhibitor indicated for the treatment of chronic hepatitis C (CHC) infection as a component of a combination antiviral treatment regimen. get Daklinza too

  • SOVALDI efficacy has been established in subjects with HCV genotype 1, 2, 3 or 4 infections, including those with hepatocellular carcinoma meeting Milan criteria (awaiting liver transplantation) and those with HCV/HIV-1 co-infection

The following points should be considered when initiating treatment with SOVALDI

  • Monotherapy of SOVALDI is not recommended for treatment of CHC.
  • Treatment regimen and duration are dependent on both viral genotype and patient population
  • Treatment response varies based on baseline host and viral factors

Treatment Duration for SOVALDI Combination Therapy

  • Patients with genotype 1 or 4 CHC= SOVALDI + peginterferon alfa + ribavirin (12 weeks)
  • Patients with genotype 2 CHC= SOVALDI + ribavirin (12 weeks)
  • Patients with genotype 3 CHC= SOVALDI + ribavirin (24 weeks)
  1. SOVALDI in combination with ribavirin for 24 weeks can be considered for CHC patients with genotype 1 infection who are interferon ineligible
  2. Should be used in combination with ribavirin for treatment of CHC in patients with hepatocellular carcinoma awaiting liver transplantation for up to 48 weeks or until liver transplantation, whichever occurs first.
  3. A dose recommendation cannot be made for patients with severe renal impairment or end-stage renal disease. Buy Sovaldi Online

Dose of Ribavirin is weight-based (<75 kg = 1000 mg and ≥75 kg = 1200 mg). The daily dose of ribavirin is administered orally in two divided doses with food. Patients with renal impairment (CrCl ≤ 50 mL/min) require ribavirin dose reduction; refer to ribavirin prescribing information.

CONTRAINDICATIONS

When SOVALDI is used in combination with ribavirin or peginterferon alfa/ribavirin, the contraindications applicable to those agents are applicable to combination therapies. Refer to the prescribing information of peginterferon alfa and ribavirin for a list of their contraindications.

SOVALDI combination treatment with ribavirin or peginterferon alfa/ribavirin is contraindicated in women who are pregnant or may become pregnant and men whose female partners are pregnant because of the risks for birth defects and fetal death associated with ribavirin.

OVERDOSAGE

The highest documented dose of sofosbuvir was a single supratherapeutic dose of sofosbuvir 1200 mg administered to 59 healthy subjects. In that trial, there were no untoward effects observed at this dose level, and adverse events were similar in frequency and severity to those reported in the placebo and sofosbuvir 400 mg treatment groups. The effects of higher doses are not known.

No specific antidote is available for overdose with SOVALDI. If overdose occurs the patient must be monitored for evidence of toxicity. Treatment of overdose with SOVALDI consists of general supportive measures including monitoring of vital signs as well as observation of the clinical status of the patient. A 4-hour hemodialysis session removed 18% of the administered dose.

What is the most important information I should know about SOVALDI? 

SOVALDI, in combination with ribavirin or peginterferon alfa and ribavirin, may cause birth defects or death of your unborn baby. If you are pregnant or your sexual partner is pregnant or plans to become pregnant, do not take these medicines. Best Place to Buy Sovaldi Online says You or your sexual partner should not become pregnant while taking SOVALDI with ribavirin or in combination with peginterferon alfa and ribavirin, and for 6 months after treatment is over.

  • Females and males must use 2 effective forms of birth control during treatment and for the 6 months after treatment with SOVALDI and ribavirin or in combination with peginterferon alfa and ribavirin. Talk to your healthcare provider about forms of birth control that may be used during this time.
  • Females must have a negative pregnancy test before starting treatment with SOVALDI and ribavirin or in combination with peginterferon alfa and ribavirin, every month while being treated, and for 6 months after your treatment ends.
  • If you or your female sexual partner becomes pregnant while taking or within 6 months after you stop taking SOVALDI and ribavirin, or SOVALDI in combination with peginterferon alfa and ribavirin, tell your healthcare provider right away. Buy Sovaldi Online The Ribavirin Pregnancy Registry collects information about what happens to mothers and their babies if the mother takes ribavirin while she is pregnant. If you are also infected with HIV and taking medicines to treat your HIV infection.

Who should not take SOVALDI? 

What should I tell my healthcare provider before taking SOVALDI? Before taking SOVALDI, tell your healthcare provider if you:

  1. Have liver problems other than hepatitis C infection
  2. Have had a liver transplant
  3. Have severe kidney problems or you are on dialysis
  4. Have HIV
  5. Have any other medical condition
  6. Are breastfeeding or plan to breastfeed. It is not known if SOVALDI passes into your breast milk. You and your healthcare provider should decide if you will take SOVALDI or breastfeed. You should not do both. Buy Sovaldi Online

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Other medicines may affect how SOVALDI Works.

Especially tell your healthcare provider if you take any of the following medicines:

  • Amiodarone (Cordarone, Nexterone, Pacerone)
  • Carbamazepine (Carbatrol, Epitol, Equetro, Tegretol)
  • Oxcarbazepine (Trileptal, Oxtellar XRTM)
  • Phenytoin (Dilantin, Phenytek)
  • Phenobarbital (Luminal)
  • Rifabutin (Mycobutin)
  • Rifampin (Rifadin, Rifamate, Rifater, Rimactane)
  • Rifapentine (Priftin)
  • St. John’s wort (Hypericum perforatum) or a product that contains St. John’s wort
  • Tipranavir (Aptivus)

How should I take SOVALDI? 

  1. Take 1 tablet of SOVALDI 1 time each day only, with or without food.
  2. Take SOVALDI exactly as your healthcare provider tells you to take it. Do not change your dose unless your healthcare provider tells you to.
  3. Do not stop taking SOVALDI without first talking with your healthcare provider. If you think there is a reason to stop taking SOVALDI, talk to your healthcare provider before doing so.
  4. If you miss a dose of SOVALDI, take the missed dose as soon as you remember the same day. Do not take more than 1 tablet (400 mg) of SOVALDI in a day. Take your next dose of SOVALDI at your regular time the next day.
  5. If you take too much SOVALDI, call your healthcare provider or go to the nearest hospital emergency room right away

What are the possible side effects of SOVALDI?

The most common side effects of SOVALDI when used in combination with ribavirin include:

  • Tiredness
  • Headache

The most common side effects of SOVALDI when used in combination with peginterferon alfa and ribavirin include:

  • Tiredness
  • Headache
  • Difficulty sleeping
  • Nausea
  • low red blood cell count

How should I store SOVALDI?

  1. Store SOVALDI at room temperature below 86oF (30oC).
  2. Keep SOVALDI in its original container.
  3. Do not use SOVALDI if the seal over the bottle opening is broken or missing.
    Keep SOVALDI and all medicines out of the reach of children.

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